Colorectal Adenomas Contain Multiple Somatic Mutations That Do Not Coincide with Synchronous Adenocarcinoma Specimens

نویسندگان

  • José P. Vaqué
  • Nerea Martínez
  • Ignacio Varela
  • Fidel Fernández
  • Marta Mayorga
  • Sophia Derdak
  • Sergi Beltrán
  • Thaidy Moreno
  • Carmen Almaraz
  • Gonzalo De las Heras
  • Mónica Bayés
  • Ivo Gut
  • Javier Crespo
  • Miguel A. Piris
چکیده

We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient. Observations in these cases imply that considering not only the number of mutations but an effective oncogenic combination of mutations can determine the malignant progression of colorectal lesions.

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Correction: Colorectal Adenomas Contain Multiple Somatic Mutations That Do Not Coincide with Synchronous Adenocarcinoma Specimens

Copyright: © 2015 Vaqué et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2015